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. Recall that, according to the theory, all genes not being expressed--that is, used as a template for making proteins in the cell--should be accumulating mutations and degenerating
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. Despite the large amounts of ACYI that exist in mammalian kidney and liver, the reactivation of ACYI is particularly difficult in vitro (19-21), which suggests that the folding of ACYI in vivo might be assisted by the possible intracellular molecular chaperones and/or osmolytes
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. Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomain
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. Key words: asthma; COPD; cystic fibrosisAbbreviations: CF = cystic fibrosis; CFTR = cystic fibrosis transmembrane regulator; Gas6 = growth-arrest-specific-factor 6; GTPase = guanosine triphosphatase; HGF = hepatocyte growth factor; IL = interleukin; LRP = lipoprotein receptor-related protein; MFG = milk-fat-globule-factor; PPAR = peroxidase proliferator-activated receptor; PS = phosphatidylserine; PSR = phosphatidylserine receptor; SP = surfactant protein; TGF = transforming growth factor; TNF = tumor necrosis factor; VEGF = vascular endothelial growth factor**********Cell death, removal, and replenishment are increasingly recognized as fundamental processes in both the developing and the developed organism
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. Over 100 years ago, Metchnikoff recognized the importance of the homeostatic removal of dead cells, which he termed physiologic inflammation
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. Efferocytosis is impaired in several COPD animal models, including SP-D knockout mice (24) TNF-[alpha]-overexpressing mice (K
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. We examined two single point cavity-forming mutants, I7S and F110S, whose internal cavities of 40 and 100 [Angstrom], respectively, appear to be fully hydrated (18), and the double mutant C3A/C26A in which the disulfide bridge linking strands β1 and β2 has been severed
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. Since then, Xenopus oocytes and other large single cells like Aplysia californica neurons (300 µm in diameter) have been used in numerous quantitative water MRI studies that mapped the apparent diffusion coefficients or spin-spin and spin-lattice relaxation times of intracellular water (9-13)
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. Apparent mitochondrial asymmetry in Xenopus eggs
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. Although the other monocations may be involved with DNA binding solely through electrostatic force, there may be some other possibilities with Li+ ion, and the position of Li+ ion in this monocation activity sequence seems to depend strongly on the detection method and experimental conditions
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. Hydration and structure-the two sides of the insulin aggregation process
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. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobia surfaces
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. These BCAAs also play a role in weight management and lean/fat body composition
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. Manuscript approved for publication 2 March 2004 by the Scientific Editor
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