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We compare the costs involved in similar surgical cases
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Similar results have been observed in 1), the enzyme malate synthase G (54), a close structural analog of pyruvate dikinase and EIC (11), where binding to pyruvate does not cause large structural changes (55); and 2), the pyruvate dikinase from maize, where only small changes are observed in selected regions upon binding of PEP (56)
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J Clin invest 1995; 96:1631-1638(47) Schrijvers DM, De Moyer CR, Kockx MM, et al
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These azurins maintain an intact native fold (x-ray structure) but are ~6 kcal/mole less stable relative to the wild-type (WT) (18-22)
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Glycoforms modify the dynamic stability and functional activity of an enzyme
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Finally, they were cleaned by ethanol and dried properly to remove any contamination
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The fluorescent dye, 4,6'-diamidino-2-phenylindole (DAPI) was obtained from Wako Pure Chemical Industries (Osaka, Japan)
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DCVJ and ThT bound to aggregated TTR shows markedly similar fluorescence lifetimes which were overall short with at least three components (Fig
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6 A, where the degree of dissociation was calculated as described in the methods
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4 acting as lateral scaffolds for formation of following fibrils, which at the same time ensures ordered, parallel organization of large domains of fibrils
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In this case the mutual diffusion of the helical and β-sheet portions of the protein is the dynamical process responsible for the gutter-like feature on the reduced folding surface
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In the hypergutter model, the "transition state" is, by definition, the subspace after that which takes the longest time to search-the rate-determining step
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It suggests interpretations for Φ-values of order 0
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2] temperatureof sea(at 10 mCruise surface)depth) Depth (m)SM-IX7
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Increasing the molecular weight of the IPP polymer did not significantly change T^sub g^
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The change means lower reimbursements for retail pharmacies--particularly because ASP doesn't distinguish among different classes of trade
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