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. Pathways of protein folding
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. Remarkably, there is a 20% chance of linding a cavity of radius a = 12
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. The high response of tetrameric proteins may suggest a particular destabilization of the native structure associated to the oligomeric state, a perturbation probably related to dissociation of the subunits and exposure of previously buried hydrophobic regions
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. These values are very similar to those found in the core of small well-structured proteins
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. The increase in Na+ activity is rather steep compared to the moderate changes in activity between K+, Rb+, and Cs+
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. We also determined the pressure range in which the proteins remain membrane bound: PLCβ binding was stable throughout the 1-2000 bars range, Gβγ binding was stable only at high membrane concentrations, whereas Gagr;^sub s^(GDP) dissociated from membranes above 1 kbar
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. The lateral association is seen in the corresponding AFM images after 30 min at 60°C, but already after -20 min at 70°C
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. Underlined items in the "Abundance" column indicatethat some or all of the specimens were preserved and at least oneindividual was correctly identified as Pseudopercis semifasciata
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. In other words, the second MD trajectory segment covers a small subspace of the conformational space sampled by the first segment and hence reduces the overall size of the elements of the covariance matrix σ through averaging over the combined trajectories
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.001 NSAIDs 95%CIEffect of Type 1 RPCumulative effect over all months -$10,900,000-$4,098,872Cumulative effect per year -$1,505,318-$565,362Effect of Type 2 RPCumulative effect over all months -$24,800,000 -$20,600,000Cumulative effect per year -$4,378,332-$3,636,312Table 5: Effect of RP on Patient NSAID ExpendituresNSAIDs Estimate p-ValueEffect of Type 1 RPCumulative effect over all months $666,340
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