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. The authors thank Jacques Colletier for useful discussions on cholinesterase biochemistry as well as the IN16 instrumental team (Bernhard Frick, Thilo Seydel, and Matthias Elender) and the IN13-CRG team (Marc Bée, Francesca Natali, and Sebastien Vial) at the Institute Laue-Langevin, Grenoble, France
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. Thus, the effective size of the monocation in compact DNA is expected to be closer to the size of free ion without hydration shell, where the sequence of the monocation radius is Li+ CONCLUSIONOur investigation highlights the inverse relation between DNA compaction potentials of monovalent cations in a crowded environment and the previously reported DNA binding properties of different alkali ions
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. The specific signal obtained from ThT binding to amyloid fibrils should therefore be a combined effect of decreased rotational relaxation and decreased polarity of the surrounding environment
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