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Control experiments revealed a similar increase in thiol reactivity in the presence of 1 M KCl (data not shown)
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The occurrence of such states depends upon the range and strength of the attractive and repulsive forces acting between the particles
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In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development
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Journal of Experimental Psychology: Human Perception and Performance, 9, 137-144
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.6^, δ) for Fyn SH3 domain
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. This scaling ensures that claims of persistent, long-range contacts are not predicted by theories for polymers in the EV limit
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. Structure of EI^sup SC^ by FTIR (steady-state measurements) In Fig
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. Mass normalized fluorescence profiles are shown in Fig
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. Our gradient coil capacity allows still higher gradient strengths, but these cause larger eddy currents and possibly also signal distortions in MRS experiments
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.A surprising result is the rank order of the kinetic disk stability ΔG* ~ln τ that is evident from the timescales of the heat denaturation, apoA-1 > apoA-2 > apoC-1 (Fig
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. This is not, of course, to suggest that the path is unique, since: 1), a large fraction of each subdimension may be explored; 2), the path is at each stage reversible; 3), degrees of freedom inessential to the current dimensional reduction are not "frozen" but are freely exploring their configurations; and 4), the nondiffusive "zipper" dimensions describing the local folding of secondary structure are perpetually exploring their own configurational space rapidly and cooperatively with the slow dimensions
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. Of the three helical junction variants studied, the four-way junction strongly favored folding to a docked conformation of the two loops, required for catalytic activity
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