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. This has been shown to alter the conformational stability of HuBChE (35), and to raise stability against thermal denaturation by 10°C from 63 to 73°C (18)
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. From these three figures, it is evident that both the experimental and the modeling results show very good agreement as they very suitably match
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. Furthermore, several residues in CaM also undergo conformational exchange on a timescale of ~50 µs
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. Molten globule monomers have been proposed as intermediates in the dissociation of some dimeric proteins, including human superoxide dismutase (Silva et al
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. We speculate that under folding conditions, it is the typological distinction between the native and highly denatured states that provides part of the driving force for folding via collapse and symmetry breaking
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