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. Since contact order is well-established as a "single value descriptor of topological complexity" (68)
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. The presence of exchange between multiple-target sites and flexibility in the bound state leads to an important advantage over rigid binding, namely that the affinity (and specificity) is finely tuned
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. The fluorescence lifetime of ANS was found to be the longest and therefore the most reliable in trying to resolve rotational correlation times of TTR oligomers and larger assemblies
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. It was also shown how molecular rotors such as DCVJ can be used as "aggregation probes" for amyloidogenic systems
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. Unlike the majority of interstellar clouds, which serve as nurseries for new stars and measure some 10 to 30 light-years across, most cemeary globules span only about one-tenth that distance and lack sufficient gas and dust to form stars
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- * In Washington, the city's insatiable housing market prompted St
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. In 2000, the Seniors Coalition received more than $2 million from the trade group, around 15 percent of its revenue
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. These maps show regions where contacts are either present (strong) or absent (weak) in both the native and denatured states
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. To minimize localization errors, an rf bandwidth of 11 kHz was chosen, which required gradients of up to 1
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. Activity of the native batch (258 U/mg) was not significantly reduced by the neutron scattering experiments
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.A single set of CaM resonances, such as we observe, implies fast exchange and/or slow exchange to a lowly populated state (33,34)
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. Determining the magnitude of the fully asymmetric diffusion tensor from heteronuclear relaxation data in the absence of structural information
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. It is however notable that the ThT molecule also responds to early oligomers (Fig
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. We treated Gα^sub s^(GDP) with dithiothreitol (see Philip and Scarlata, 2004) and found that its pressure behavior was unchanged (data not shown)
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., K^sub d^(app) ~ 7 nM) previously determined by FRET (Runnels and Scarlata, 1998)
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. Samples were fixed in a solution of 5% formalin to seawater
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. 4 D), on the other hand, a smooth continuation at 8 ns of the configurational entropy buildup is observed when the complex trajectory is appended to the free one (solid line), whereas a slight stepwise increase is visible when the trajectories are appended in the reverse order (dashed line)
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.The peak position for the SL 3WJ remains in the low-FRET region of the histograms, independent of the Mg^sup 2+^ concentration, indicating that this ribozyme construct is incapable of folding to a compact structure (Fig
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.No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article
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. However, magnitude of the relationship (correlation) between student-life stress and the mental component of HRQOL did not vary significantly across the three years in the Pharm
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. Whereas Langer (1975) focused upon the irrationality of players' cognitive processes, sociologists (e
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