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Accurate models for denatured states also impact a range of areas, including quantitative studies of in vitro folding pathways (10,19-24), protein design (25,26), studies of protein aggregation (27-29), and understanding preferential interactions in cosolute mixtures (1,3,30-36) florida department of health .
The latter is a model for a soft, Gaussian coil with large-scale, albeit uncorrelated florida department of health .
Similar data were obtained for all protein sequences shown in Table 1 florida department of health .
As a consequence the corresponding emission spectra that were measured during unfolding appear completely different (Fig florida department of health .
This process may ensue in widespread deformations of the native fold with the creation of a large number of ANS binding pockets florida department of health .
In another MD simulation, Tai et al florida department of health .
Prear, The Mechanics of Solder Alloy Wetting and Spreading (New York: Van Nostrand Reinhold, 1993), pp florida department of health .
It is well known that during DNA compaction the molecular volume of DNA molecules dramatically decreases and compact DNA represents an extremely tightly packed polymer chain that approaches the physical limits of molecular compaction florida department of health .
Human carbonic anhydrase II is considerably expanded by the interaction of GroEL florida department of health .
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The monomers are prone to fast oligomerization florida department of health .
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Concomitantly, the third hypervariable loop (V3) undergoes a rearrangement to a somewhat different conformation leading to accessibility of the epitope for co-receptor binding florida department of health .
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