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Possible functions of nativelike states of proteins have been proposed, but not clearly demonstrated
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In the red blood cells of people carrying the gene, mutant hemoglobin molecules stick together to form rodlike bundles that deform the red blood cells into the shape of a sickle
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In spite of its harmful effects, the gene persists among human populations in parts of Africa with a high incidence of malaria
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Cloning and sequence analyses of cDNAs encoding aminoacylase I from porcine kidney
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In essence, the structure consisted of an α-helix subdomain, which is a four-helix bundle, comprising α-helices 1-4; an α/β subdomain, comprising a β-sandwich, formed by a four-stranded parallel β-sheet (β-strands 1-4) and a three-stranded antiparallel β-sheet (β-strands 1, 5, and 6), and three short helices (α-helices 5-7) that contain the phosphorylation site (His^sup 186^) (Fig
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Either we could not unambiguously determine the protein-concentration independence of the thermal midpoint from fluorescence measurements (see above, for the values, and Fig
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1 ppm, and the aceturate peaks (a, d, and e) at 1
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5 ns, S^sup 2^^sub s^ = 0
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However, these binding modes are essentially different from those of CaM-SEF2-lmp, because the target-binding proteins do not undergo large-scale motion in the bound state
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013 atm) forces solvent into intersubunit voids resulting in subunit dissociation
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This is because the rate-determining diffusive searches will in general be completed only when a topological, as well as a spatial, constraint in the final native state is satisfied for the first time
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We therefore used the Newey-West autocorrelation consistent covariance matrix estimator (Newey and West 1987) throughout to ensure that hypothesis testing was valid in the presence of up to a 4 month autocorrelation
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Most of the savings from the introduction of RP were therefore attributable to substitutions of low cost unrestricted for higher cost restricted NSAIDs
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02# 101# Type 2 RPDelistingsNov 95- Nov 96-Oct 96Jun 01Analgesic CategoryNSAIDSUnrestrictedASA ect 650 mg tab 0
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Because birds scavenge dead farm animals, "any NSMD that is used without testing [on birds] is a real cause of concern," Cuthbert says
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Over time, the brain gets used to having all the extra dopamine around
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"Timely, accurate diagnosis can mean the difference between patient admission and discharge, between relief of symptoms and prolonged suffering, between early intervention and missed therapeutic opportunities and, in the gravest instances, between life and death
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MEETINGS, ANGER MANAGEMENT AND PARENTING CLASSES, AND SEXUAL DEVIATION AVOIDANCE SEMINARS
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Q What kinds of tools and resources has AstraZeneca developed for pharmacists?Based on our conversations within the pharmacy community, we developed a suite of resources and tools that we thought would help fill the gaps and would do so in a manner that was user-friendly for the pharmacist
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Dental student stress, burnout, and memory
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"ASP reflects, at best, the average price paid for drugs by pharmacies, HMOs, hospitals, managed care plans and other purchasers
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Indeed, wherever they turn up, video-poker machines incite stiff reaction, and not only from religious activists
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Psychologically, there may be several reasons for this conservative approach
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A fourth is in the works
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1991/1999 All225Enopi Daekyo USA Inc
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. A schematic diagram with the primary structure of the glycan is shown in Fig
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. However, the mean-field Flory random-coil model is not well-suited for explaining the source of scale-invariant behavior of denatured proteins
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. Since the diameter of this gorge, at its narrowest point, is smaller than the cross-section of the quaternary group of ACh, substantial breathing motions of the whole AChE catalytic subunit are necessary to allow the substrate to penetrate to the active site
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.Size and morphology of special aggregates and protofibrilsAliquots from a TTR aggregation reaction solution taken after 30 min, 2 h, 24 h, and 430 h were investigated using transmission electron microscopy (Fig
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