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. The difference in configurational entropy between two molecular conformations a and b can be estimated as ΔS = k^sub B^/2 ln(detσ^sub a^/detσ^sub b^), where σ^sub a^ and σ^sub b^, are the covariance matrices of atomic positional fluctuations of the two conformers and k^sub B^ is Boltzmann's constant
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