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. When considering all protein atoms, the number of atoms in gp120 becomes too large to obtain sufficient sampling in the timescale of our simulation (10 ns); the buildup curves have not yet converged (Fig
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. At the moment, however, we do not know whether these small changes in the structure are also responsible for the observed considerable specificity of the phosphotransfer reaction between EI and HPr among the different species and the differences in their cnthalpic variations in their binding reactions (45
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