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Whether asking a vendor for extended payment terms or for an early-pay discount, entrepreneurs have to assess whether a supplier's demands are realistic
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. It is worth noting that a multi-event equilibrium unfolding/ dissociation of human GR by GdnHCl has been previously reported (Nordhoff et al
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. Protein glycosylation is more profuse and structurally more complex than all other types of posttranslational modifications taken together (1-3)
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. This is the case if at least one major component of the surrounding solvent is chemically equivalent to the main repeating unit of the polymer making chain-solvent contacts preferable to chain-chain contacts (4,37)
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. The average volume occupied by the chain will be filled inefficiently, and cavities of all sizes l > ls should be found readily within the interior of a denatured protein
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. In Protein Folding Handbook, Vol
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. 72 kcal mol^sup -1^)
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. Because the signal/noise ratio (SNR) in NMR increases inversely proportional to the micro rf coil diameter (16) and since intracellular structures scale with cell size, the dimensions of the rf coil and the biological cell size have to be precisely balanced for optimal subcellular signals
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. This is particularly intriguing, since its three-dimensional structure reveals that the active site of AChE, which, like other serine hydrolases, features a Ser-His-Glu catalytic triad, is buried at the bottom of a deep and narrow gorge lined by aromatic residues (26)
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. Are the biochemical modifications produced upon binding of soman reflected by changes in molecular dynamics?In the following, we use incoherent elastic neutron scattering (IENS) to investigate ChE molecular dynamics and to address the above issues experimentally
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. At the lower concentrations, Newtonian behavior was observed at shear rates, γ, in the range 10-100 s^sup -1^
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. Such prefibrillar oligomers could also serve as a common intermediate between the amyloidoses and other misfolding diseases, including prion diseases, Parkinson's disease, and amytrophic lateral sclerosis
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- The themed disc concept works quite well, particularly Disc Three, The Great American Songbook and Disc Four, Family and Friends
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. We also monitor liquidity ratios by payer class
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. To understand the absence of diminazene signal in both cytoplasmic compartments, macromolecule binding has to be considered once more
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. The overall effect of pH on the osmotic compressibility at 1 M NaCl is shown in Fig
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. The fibrils grown at 70°C on the same timescale are longer (up to 5
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