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The PLC-γ1 C-terminal SH2 domain (19) and Csk SH3 domain (47) bind specifically to their flexible (peptide) target to form a specific complex, again with essentially one overall conformation national institute on mental health and autism .
In addition, slower multiphase unfolding is detected at higher denaturant concentrations national institute on mental health and autism .
This is particularly relevant to emulsifiers, some of which have a melting point above 150[degrees]F national institute on mental health and autism .
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Since the docked and undocked peaks are well resolved, any interconversion between the two conformers must occur more slowly than the ~280-µs average burst duration of the single-molecule measurements (see below) national institute on mental health and autism .
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