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Through October, the company had looked at 355 origination requests, compared with 293 the previous year
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Studies show that a combination of drugs and therapy works better than drugs alone or therapy alone
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4 Å and the hydrophobic interactions have an even distribution in the range 3-6 Å
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From Levinthal to pathways to funnels
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Is protein folding hierarchic? II
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To achieve subcellular nonwater ^sup 1^H MRS, the MR setup has to be highly sensitive, invoking the need for a strong static magnetic field, strong gradients, and micro radio frequency (rf) coils
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3 µs and a repetition time of 2
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The presence of exchange between multiple-target sites and flexibility in the bound state leads to an important advantage over rigid binding, namely that the affinity (and specificity) is finely tuned
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We have found that for membranes composed of lipids with electrically neutral or negatively charged head groups, no change in surface charge could be detected at neutral pH from 1 to 2000 bar
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These approaches have one important aspect in common: they all effectively reduce the dimensionality of the search-space by assumption, rather than by derivation
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In all three years, parturition off the Oregon coast occurred between mid-January and mid-March and peaked in February
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- Says Stratigos, "[Greg] and I looked at each other, and that was the sign from the universe
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. Each of these reports provides information that assists us in the management of the revenue cycle
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. In fact, the industry has only a handful of experts that routinely conduct seminars or go on-site with customized programs
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. The first regime 0 ≤ q 0
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. Asymmetry in the shapes of folded and denatured states of proteins
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. Reference deleted in proof
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. (11) Similarly, PS on apoptotic cells may also directly bind to a an unidentified receptors or receptors on the phagocyte surface, effectively bypassing several PS-binding proteins, like MFG-E8, Gas6, thrombospondin, [[beta]
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.MATERIALS AND METHODSMaterialsBLG was obtained from Sigma-Aldrich (Poole, UK) (L0130) and is a mixture of genetic variants A and B
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.Summary of the use of ANS, Bis-ANS, DCVJ, and ThT as fluorescence conformational probesThe results of the analysis of the fluorescence response in binding to unfolded monomers, native TTR, and various stages of the aggregation reaction is summarized in Table 2
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. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin
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. Mark-recapture and telemetry studies could be used to investigate the spatial dynamics of reproductive activity of this species in the Argentine Sea
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. Several are located in the putative trimerization interface, S243, C378, and 1439, and two of them, V255 and L260, are located in the β-turn that connects the inner and outer domains of gp120
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. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
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. Also, they made no attempt to break up the gel into secondary particles
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. Conversely, pellets maintained in DMEM/10%FCS possessed limited extracellular matrix (Fig
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. There are holes we are trying to fill that are important as we move forward for revenue growth
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.We can manipulate (1) to identify the effect of RP on the expected [DaysNSDPop
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."FDA is optimistic that this progress will continue at a rapid pace and will achieve widespread use in the drug supply chain," added an agency spokesperson
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.2 million total toxic exposures annually, and nearly 10%, or 275,000 of 2
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. PhRMA doesn't dispute these estimates
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.About 80 percent of Cherry's business is generated behind the pharmacy counter
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. The difference is statistically significant when evaluated by [C
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. The results of this experiment suggest that past observations of deviations from optimal strategies (e
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