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Sterics and solvation winnow accessible con formational space for unfolded proteins
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For experiments involving PEP, control scans were acquired with PEP added to buffer versus buffer in the reference cell, and baselines were found to be the same as in buffer-buffer baselines, suggesting that under these conditions hydrolysis of PEP during heating was not significant
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1 C), consistent with the absence of such changes in repetitive CD scans
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The Θ^sub 222^(t) data show a rapid signal loss at any Gdm HCl concentration, indicating fast unfolding within the dead-time of the experiment (30 s), which precludes its quantitative analysis; the amplitude of this rapid phase increases with increasing denaturant concentration (Fig
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The adhesive strength of the toner/fiber interface is apparently sufficient to prevent separation of the toner
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Although both benign and malignant mesothelial cells expressed TGF-[alpha], significant membranous expression of EGFR occurred in malignant mesothelioma, but not in reactive mesothelial proliferations
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In order to suppress non-specific binding of IgG, the sections were blocked with normal rabbit serum (Dako AJS, Denmark), diluted 1:5 in TBS for 20 minutes
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Fourth, although the drug plan saves money on those beneficiaries who elect to pay extra for the higher cost drugs, these expenditures are merely shifted--overall drug costs do not decline
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7 million arrests a year and keeps half a million Americans behind bars for failing to comply with an arbitrary set of pharmacological preferences
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Nearly three-quarters of the doctors said that they believe that DTC ads inform people about medicines that might help them, and two-thirds of the doctors said that ads improve dialogue
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"With Medicare set to launch prescription drug coverage for 41 million seniors in January, the continuing aging of the population and the discovery of new drug compounds through pharmacogenomics and biotechnology, Bootman noted, "It's easy to understand why, over the next few years, the number of prescriptions dispensed is expected to more than double
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. Thus the sample with a concentration of 1 mg/ml was used for further analysis
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. Here, q is in units of inverse wavelength
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. SWISS- MODEL: an automated protein homology-modelling server
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. Another reason is that the solubility of Cu into the molten Sn-Pb solder (0
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., neurotoxic protofibrils of α-synuclein-Rochet et al
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.RELATIONSHIP TO OTHER MODELSWe stress that the search-space picture explored above is not incompatible with the frameworks or results of the other models discussed in the introduction, but rather serves to show how the apparently alternative models are related, and how high-dimensional features are implicit in all of them
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. In this method, the fluorescence of donor and acceptor are simultaneously recorded using avalanche-photodiodes as individual molecules traverse the excitation volume in a confocal microscope, and the FRET efficiencies from many such single-molecule observations are plotted in the form of a histogram
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.>From the Division of Head and Neck Surgery, Department of Surgery, School of Medicine, University of California at Los Angeles
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. Instead, we must consider the very genuine limitations to the application of probability theory to real-life choice behavior
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