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Cash was 12, several months after he accepted Christ, his older brother Jack--a preacher--was killed in a farming accident
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In the folded form, the average packing density is high and protein interiors are thought to he either solidlike (87,88) or like "randomly packed spheres near their percolation threshold" (89)
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Are fluctuations in the EV limit correlated? Theory predicts that the gross inefficiency with which the available volume is rilled by polymers in the EV limit is in fact a manifestation of correlations between large-scale fluctuations
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Crystal structures of pyruvate phosphate dikinase from maize revealed an alternative conformation in the swivelling-domain motion
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A measure of conformational entropy change during thermal protein unfolding using neutron spectroscopy
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From these two figures, higher dissolution of Ni substrate was observed for Sn-Ag-Cu-Bi solder and thought to be the reason that this solder obtained slightly more IMC layer thickness than did the Sn-Pb/Ni soldering system
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Stimulated by the biological importance of this subject, many in vitro investigations of DNA interaction with K+ and Na+ ions as well as other monovalent alkali cations (Li+, Rb+, and Cs+) have been performed by biophysicists (Bleam et al
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Li+ shows moderate chemical potential in PEG 3000 but is the weakest DNA compaction agent in PEG 10000
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By definition, such a transition has non-equal probability to proceed in forward and reverse directions, and thus is pathway-dependent; it does not necessarily involve irreversible chemical changes
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In conclusion, we have shown that insulin amyloidogenesis in vitro induced by the en masse destabilization of native dimers proceeds through a multipathway assembling scheme, which employs-on the one hand-the hierarchical intertwisting reported earlier; and on the other hand, employs lateral interactions of single particles and fibrils, leading to larger domains of features aligned in parallel (Fig
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Conformational-changes induced in the human-immunodeficiency-virus envelope glycoprotein by soluble CD4 binding
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In 1998 age 6-8 fish produced the largest percentage of larvae (65
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The increase in abuse of prescription painkillers by teens has been slight but at a persistent level of high use
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If blackjack and roulette were permitted during Vegas--style fundraisers for local civic organizations, Indian tribes could open full-blown casinos
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. On the other hand, tryptophan emission is quite sensitive to the polarity of the surrounding environment, and fluorescence red-shifts are indicative of increased exposure of tryptophan residues to the aqueous medium (Lakowicz, 1983)
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. Similar results have been observed in 1), the enzyme malate synthase G (54), a close structural analog of pyruvate dikinase and EIC (11), where binding to pyruvate does not cause large structural changes (55); and 2), the pyruvate dikinase from maize, where only small changes are observed in selected regions upon binding of PEP (56)
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. Importance of the carboxyl-lemiinal domain of enzyme I of the Eschericliia coli phosphocnolpyruvate:sugar phosphotransferase system for phosphoryl donor specificity
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. The impact of aggregation on fluorescence emission spectra To investigate how fluorescence emission spectra are affected by aggregation we measured the aggregation directly by the use of elastic light scattering and we analyzed unfolding transitions under different conditions which lead to a different extent of protein aggregation
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. This decrease in protein fluctuations was ascribed to a reduction in the frequency of breakage of hydrogen bonds due to steric hindrance by the glycan chains
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. Bis-ANS shows a wide variety of fluorescence responses and fluoresces most strongly when bound to monomeric A-state TTR and surprisingly also fluoresces strongly when bound to unfolded monomeric TTR
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.INTRODUCTIONHigh-density lipoproteins (HDLs) are heterogeneous complexes of lipids and specific proteins (termed exchangeable apolipoproteins) that mediate cholesterol removal from peripheral tissues to the liver via the process termed reverse cholesterol transport (Fielding and Fielding, 1995)
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