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Using these procedures, the energetics and pathways of folding, as well as the existence of transient intermediate states between unfolded and fully folded polypeptides, have been characterized for a number of proteins (for a collection of reviews, see Creighton, 1992; Pain, 1994)
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. This behavior is expected to hold for all |i - j| > n^sub s^, where n^sub s^ denotes the number of residues over which sequence context is important
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. EFFEROCYTOSIS: EXTRACELLULAR AND INTRACELLULAR MACHINERYEfferocytosisBecause the phagocytosis of apoptotic cells has distinctive morphologic features and unique downstream consequences, deCathelineau and Henson (10) and Gardai et al (11) coined the unique term efferocytosis (taken from the Latin effero, meaning to take to the grave or to bury)
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. : 82-42-865-3431; Fax: 82-42-865-3419; E-mail: cheong@kbsi
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. Although the differences in the χ^sup 2^ residuals between M2II models with different τ^sub is^ are not statistically significant, it is safe to conclude that there is a slow timescale motion present with a correlation time of roughly 2
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. Hydrodynamic calculations can provide some indication as to the structural assignment of the internal motions identified from NMR relaxation experiments (see Supplementary Material)
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. Abbreviations used: PLC, mammalian phosphoinositide-specific phospholipase C; PI(4,5)P^sub 2^, phosphatidylinositol 4,5- bisphosphate; POPC, 1-palmitoyl-2-oleoylphosphatidylcholine; POPS, 1-palmitoyl-2-oleoylphosphatidylserine; PE, 1-palmitoyl-2-oleoylphosphatidylethanolamine; PH, pleckstrin homology; DNS-PE, dansyl phosphadtiylethanolamine; FRET, fluorescence resonance energy transfer
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. Even though Gα^sub i^(GDP) did not significantly affect the PLCβ^sub 2^-Gβγ equilibrium, it unexpectedly resulted in rapid deactivation of the PLCβ-Gβγ complex when PLCβ activity was monitored (Runnels and Scarlata, 1998)
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. As in the case of the Φ-value analysis, this experiment is also usually interpreted as giving information about the transition state (Oliveberg et al
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. During those months without reproductive activity, late spring through early fall, it was difficult to distinguish between immature and mature-resting ovaries
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. A complementary approach is to characterize the conformational distributions of freely diffusing RNA molecules using a single-molecule method referred to as diffusion spFRET (Deniz et al
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. Journal of Field Ornithology 67:499-506
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. 5 ml papain digest buffer (Sodium citrate (55 mM), Sodium chloride (150 mM), Cysteine Hydrochloride (5 mM), EDTA (5 mM) (all Merck, Poole, UK)); and 1 µg/ml papain (Sigma, Poole, UK)
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. As they had during previous hearings in 2000, members of the committee fretted that patients would muck up dosages, lose track of cholesterol levels, and make poor decisions about diet and exercise if popping a pill appeared to produce the same results as a healthy lifestyle
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. On one hand, sales representatives target physicians with visits and samples, and ads tout drugs in journals
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. Prescription sales at Wal-Mart account for an estimated 4 percent of total revenues
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. "Catizone and others at the event expressed fear that expanding Albano's proposal would circumvent the Food and Drug Administration's approval and safety processes
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. In a separate address, outgoing NABP president John Fiacco cited another approach that he said holds great promise "to redefine some of the basic tenets of pharmacy and support all of those patient care services
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. , not far from its Issaquah, Wash
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. Chief information officer Mark Halloran says the Pharmacy of the Future, as the Las Vegas facility was called, involved a multipronged information systems development effort
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. Mean Student-Life Stress Inventory, PCS-12 and MCS-12 scores were compared for females and males using independent t-tests
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. It would appear that college students, while gambling for fun (intrinsic motivation) also have hopes of winning money (extrinsic motivation)
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. A total of 27 hydrogen-bonding interactions and 53 hydrophobic interactions were found to stabilize the structure, which suggests that hydrophobic interactions between the protein and the glycans are responsible for the exceptionally high stability of the glycoprotein
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. Steady-state measurements Spectra were acquired in a 0
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.5 mM of PEP and 5 mM of Mg^sup 2+^
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. The previous NMR data were consistent with two schematic models of the CaM dimer
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.Formation of an amyloid reflects an alternative to the native packing conformational struggle of a polypeptide chain to 1), reduce its surface accessible area; 2), saturate hydrogen bonding; and 3), reach an alternative non-native global free energy minimum (Gazit, 2002)
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.0] m), and 34 and 79 m in fall surveys (mean depth [[+ or -]SE]: 60
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. These observations suggest that the V3 loop undergoes major changes in conformation and/or localization upon CD4 binding, although its intrinsic flexibility persists, or even possibly increases
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. As a result, young fish can be as large or larger than much older fish (Fig
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. It takes a lot of effort from the pharmacy, the whole company [and] our supplier partners," said pharmacy merchandise manager Bruce Painter
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.The fundamental attitude and commitment of the retail pharmacy industry must shift more rapidly and more aggressively to a mindset truly dedicated and focused on customer education and communication, especially as more baby boomers age and as health care reform likely becomes a more prominent issue in the 2008 presidential elections
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. Journal of Social Psychology, 133, 507-511
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