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During a double-blind, 6-week bodybuilding study, the active compound in Endothil-CR increased upper body strength by 100% and lower body strength by 249% after concentrated exercise (as measured by the amount of weight participants could bench press and leg press)
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In addition, the peak corresponding to tryptophan emission displayed a significant red-shift to [lambda]^sub max^ ~ 334-339 nm
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Not all the possible pleiotropic effects of Hh in cave fish are known, but suggestive scenarios abound
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The sensitivity of the ANS binding method to the tertiary structure of proteins in ice should find practical utility in devising safer freeze-drying protocols of pharmaceutical proteins and testing the effectiveness of various stabilizing/ destabilizing agents employed in protein formulations
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Spatial localization in NMR spectroscopy in vivo
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Although this value of specific volume is required to approximate the viscous behavior at intermediate protein concentrations, the specific volume used for approximating the concentration-dependent osmotic pressure (1
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Gβ^sub 1^γ^sub 2^, termed Gβγ, was expressed in StV cells using a baculovirus system and purified as previously described (see Runnels et al
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The concentration dependence of binding closely matches the activation profile (Runnels and Scarlata, 1998)
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, 2004), supported by the earlier studies of apoA-1:DMPC disks (Reijngoud and Phillips, 1982; Epand, 1982; Surewicz et al
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Timing of parturition was estimated by microscopically determining embryo development stages for all females with fertilized eggs following Yamada and Kusakari's (1991) stages of embryonic development for kurosoi (Sebastes schlegeli) modified to reflect the gestation period of 37 days for black rockfish (Boehlert and Yoklavich, 1984)
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These data were fitted with a cooperative binding model, and the resulting fits are shown as solid lines in Fig
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Levy, is also with the Department of Health Care and Epidemiology, University of British Columbia, BC, Canada
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This includes data on body fluid concentrations of substances in normal or therapeutic situations, concentrations in fluids and tissues in instances of toxicity, toxic effects, chemical structures, and brief discussion of analytic procedures for the determination of substances in biological specimens
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"People don't think Manhattan has a lot of families, but they are abundant," said Tabouchirani
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Self-report measures may only approximate the rate of gambling behavior, and can be influenced by extraneous factors
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. Since the frequency of the solvent-exposed secondary structures is smaller than the buried ones (44,45), the above sequential events could be interpreted as follows: the unfolding of the solvent-exposed β-sheet structures is the earliest event, followed by the formation of aggregates, and finally the unfolding of the other native structures
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. However, the molar ellipticity at 222 nm at basic pH was larger (in absolute value) than that at pH 7
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. However, it has been shown in various cases that (and how) under specific conditions λ^sub max^-signals can be used for quantitative analyses of unfolding transitions (4,12,15)
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. The stabilization of state C is probably due to an increase of its entropy, related to larger MSDs (in line with neutron scattering experiments on denatured α-amylase, (51))
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. In solution, this helix is disrupted in the middle (2), which allows N- and C-terminal domains of both apo-CaM and Ca^sup 2+^/CaM to tumble almost independently of each other (3-5)
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. Protein association to membranes is stabilized by a combination of electrostatics as well as polar and hydrocarbon interactions
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.The peak position for the SL 3WJ remains in the low-FRET region of the histograms, independent of the Mg^sup 2+^ concentration, indicating that this ribozyme construct is incapable of folding to a compact structure (Fig
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